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(S)-2-amino-2-(thiophen-2-yl)acetic acid; CAS No.: 43189-45-3; (S)-2-amino-2-(thiophen-2-yl)acetic acid. PROPERTIES: (S)-2-amino-2-(thiophen-2-yl)acetic acid is a crystalline powder with a molecular weight of approximately 173.2 g/mol. It has a melting point between 140-145 C. The compound is moderately soluble in water and exhibits optical activity due to the chiral center. The amino and carboxylic acid groups impart zwitterionic character at physiological pH. For proper storage, keep in a tightly sealed container at room temperature away from heat and moisture. Safety: This compound may cause skin irritation and serious eye damage. In case of accidental ingestion, rinse mouth immediately and seek medical advice. Use personal protective equipment including safety glasses and laboratory coats. APPLICATIONS: In pharmaceutical research, (S)-2-amino-2-(thiophen-2-yl)acetic acid serves as a building block for creating ACE inhibitors. The thiophene ring provides structural similarity to substrate molecules. In organic synthesis, it is used as a chiral building block for creating bioactive molecules. The amino and carboxylic acid groups facilitate peptide bond formation. In materials science, derivatives of this compound are explored for creating chiral catalysts. The combination of the thiophene ring and the amino group creates a chiral environment that influences catalytic selectivity. These applications are supported by research in medicinal chemistry journals and catalysis publications.