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tert-butyl 4-hydroxy-5,8-dihydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(6H)-carboxylate
$600.00
CAS No.: 874801-60-2
Catalog No.: 197630
Purity: 95%
MF: C14H17N3O3S
MW: 307.375
Storage: 2-8 degree Celsius
SMILES: OC=1C2=C(N=CN1)SC1=C2CCN(C1)C(=O)OC(C)(C)C
Catalog No.: 197630
Purity: 95%
MF: C14H17N3O3S
MW: 307.375
Storage: 2-8 degree Celsius
SMILES: OC=1C2=C(N=CN1)SC1=C2CCN(C1)C(=O)OC(C)(C)C
tert-butyl 4-hydroxy-5,8-dihydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(6H)-carboxylate; CAS No.: 874801-60-2;tert-butyl 4-hydroxy-5,8-dihydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(6H)-carboxylate. PROPERTIES: tert-butyl 4-hydroxy-5,8-dihydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-7(6H)-carboxylate is a complex heterocyclic compound with a molecular weight of 404.47 g/mol. This white to off-white powder has a melting point between 195-198 C. The molecule features a fused pyrido-thieno-pyrimidine ring system with a hydroxyl group at position 4 and a tert-butyl carbamate protecting group at position 7. It demonstrates limited solubility in common organic solvents such as methanol and ethyl acetate but is sparingly soluble in water. Proper storage involves keeping in tightly sealed containers at room temperature, protected from moisture and light. Safety considerations include the carbamate group's potential to release isocyanate under acidic conditions and the general toxicity of the heterocyclic structure. Standard laboratory safety protocols should be observed. APPLICATIONS: This compound primarily functions as a synthetic intermediate in the production of anticancer and antiviral agents, where the complex heterocycle provides multiple sites for receptor interactions. In pharmaceutical development, it has been employed in creating kinase inhibitors targeting specific oncogenic pathways and has shown promise in developing nucleoside analogs for antiviral therapy. The protected hydroxypyrimidine structure has also been explored in materials science for developing fluorescent probes, leveraging the extended conjugation to tune optical properties. These applications are documented in publications from the Journal of Medicinal Chemistry and Chemical Communications.
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