2-(4-oxo-2-thioxothiazolidin-3-yl)acetic acid
$200.00
CAS No.: 5718-83-2
Catalog No.: LT0268
Purity: 95%
MF: C5H5NO3S2
MW: 191.233
Storage: 2-8 degree Celsius
SMILES: O=C1N(C(SC1)=S)CC(=O)O
Catalog No.: LT0268
Purity: 95%
MF: C5H5NO3S2
MW: 191.233
Storage: 2-8 degree Celsius
SMILES: O=C1N(C(SC1)=S)CC(=O)O
CAS NO.: 5718-83-2;2-(4-oxo-2-thioxothiazolidin-3-yl)acetic acid. PROPERTIES: This thioxothiazolidone carboxylic acid presents as a white crystalline solid with a molecular weight of approximately 217.2 g/mol. The 2-(4-oxo-2-thioxothiazolidin-3-yl)acetic acid combines a thiazolidinone framework with a thione and carboxylic acid groups. It exhibits limited aqueous solubility until pH < 4 but dissolves well in DMSO and DMF. Stability characterization reveals vulnerability to acid-catalyzed ring-opening and base-promoted decarboxylation, necessitating storage at 2-8 degree Celsius in sealed glass containers. Handlers should use powder hoods with HEPA filtration and wear cut-resistant gloves during handling. Skin contact may cause localized edema requiring corticosteroid application. Inhalation may induce respiratory alkalosis; treatment includes humidified oxygen administration. Eye exposure requires chelation inhibitors and ophthalmology evaluation. Waste should be hydrolyzed with dilute acid prior to disposal. APPLICATIONS: The 2-(4-oxo-2-thioxothiazolidin-3-yl)acetic acid serves as a key intermediate in the synthesis of various pharmaceuticals. Its thiazolidinone framework provides opportunities for constructing antiparasitic agents and antibacterial drugs. Research teams utilize this compound as a starting material for creating thiazolidinedione-based antidiabetic agents and antiparasitic drugs. The carboxylic acid group undergoes esterification or amide bond formation for further functionalization. Additionally, it serves as a building block for creating GABA receptor modulators with enhanced subtype selectivity and fluorescent probes for bioimaging applications.
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