methyl 2-(chloromethyl)thiazole-4-carboxylate
$300.00
CAS No.: 321371-29-3
Catalog No.: 196073
Purity: 95%
MF: C6H6ClNO2S
MW: 191.639
Storage: 2-8 degree Celsius
SMILES: ClCC=1SC=C(N1)C(=O)OC
Catalog No.: 196073
Purity: 95%
MF: C6H6ClNO2S
MW: 191.639
Storage: 2-8 degree Celsius
SMILES: ClCC=1SC=C(N1)C(=O)OC
methyl 2-(chloromethyl)thiazole-4-carboxylate; CAS No.: 321371-29-3; methyl 2-(chloromethyl)thiazole-4-carboxylate. PROPERTIES: Methyl 2-(chloromethyl)thiazole-4-carboxylate is a colorless liquid with a molecular weight of approximately 190.6 g/mol. It has a boiling point around 110-120 C at 760 mmHg and a density of approximately 1.25 g/cm?. The compound is moderately soluble in organic solvents such as ethyl acetate and tetrahydrofuran but has limited water solubility. It is sensitive to hydrolysis, particularly under basic conditions, which may release hydrochloric acid. Recommended storage is in amber glass bottles under nitrogen atmosphere at 2-8 C. Safety: This compound may cause skin burns and eye damage. In case of contact with skin, immediately wash with plenty of water and remove contaminated clothing. Use explosion-proof equipment and avoid contact with heat, sparks, or flames. APPLICATIONS: In organic synthesis, methyl 2-(chloromethyl)thiazole-4-carboxylate serves as a key intermediate for creating -lactam antibiotics. The chloromethyl group undergoes nucleophilic substitution reactions to form the -lactam ring system. In pharmaceutical research, it is used to synthesize prodrugs that enhance gastrointestinal absorption. The ester group is hydrolyzed in the body to release the active compound. In materials science, it is employed in creating polymerizable monomers with antimicrobial properties. The thiazole ring provides structural features that inhibit bacterial growth. These applications are supported by research in organic chemistry journals and pharmaceutical literature.
Reviews
Write Your Own Review