ethyl 2-bromo-4-(trifluoromethyl)thiazole-5-carboxylate
$360.00
CAS No.: 72850-79-4
Catalog No.: 196086
Purity: 95%
MF: C7H5BrF3NO2S
MW: 304.087
Storage: 2-8 degree Celsius
SMILES: BrC=1SC(=C(N1)C(F)(F)F)C(=O)OCC
Catalog No.: 196086
Purity: 95%
MF: C7H5BrF3NO2S
MW: 304.087
Storage: 2-8 degree Celsius
SMILES: BrC=1SC(=C(N1)C(F)(F)F)C(=O)OCC
ethyl 2-bromo-4-(trifluoromethyl)thiazole-5-carboxylate; CAS No.: 72850-79-4; ethyl 2-bromo-4-(trifluoromethyl)thiazole-5-carboxylate. PROPERTIES: Ethyl 2-bromo-4-(trifluoromethyl)thiazole-5-carboxylate is a crystalline solid with a molecular weight of approximately 303.0 g/mol. It has a melting point between 80-85 C. The compound is moderately soluble in common organic solvents like dichloromethane and acetone but is practically insoluble in water. The trifluoromethyl group imparts significant lipophilicity to the molecule. For proper storage, keep in a tightly sealed container at room temperature away from heat sources. Safety: This compound may cause serious eye irritation. In case of contact with eyes, rinse cautiously with water for several minutes and remove contact lenses if present. Use explosion-proof ventilation and lighting if handling large quantities. APPLICATIONS: In pharmaceutical research, ethyl 2-bromo-4-(trifluoromethyl)thiazole-5-carboxylate serves as a lead compound for creating antifungal agents. The trifluoromethyl group enhances penetration through fungal cell membranes. In organic synthesis, it is used as a building block for creating bioactive molecules. The bromine substituent allows for cross-coupling reactions to introduce therapeutic groups. In materials science, derivatives of this compound are explored for creating liquid crystalline materials. The combination of the thiazole ring and the trifluoromethyl group creates anisotropic molecules suitable for liquid crystal applications. These applications are documented in medicinal chemistry journals and materials science research articles.
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