4-bromo-2-chlorothiazole
$250.00
CAS No.: 92977-45-2
Catalog No.: 197624
Purity: 95%
MF: C3HBrClNS
MW: 198.472
Storage: 2-8 degree Celsius
SMILES: BrC=1N=C(SC1)Cl
Catalog No.: 197624
Purity: 95%
MF: C3HBrClNS
MW: 198.472
Storage: 2-8 degree Celsius
SMILES: BrC=1N=C(SC1)Cl
4-bromo-2-chlorothiazole; CAS No.: 92977-45-2;4-bromo-2-chlorothiazole. PROPERTIES: 4-bromo-2-chlorothiazole is a halogenated heterocycle with a molecular weight of 274.55 g/mol. This colorless to pale yellow liquid has a boiling point around 145-147 C at 760 mmHg. The thiazole ring features a bromo substituent at position 4 and a chloro group at position 2. It demonstrates good solubility in common organic solvents such as chloroform and acetone but limited water solubility. The compound is sensitive to moisture and should be stored in tightly sealed containers under inert atmosphere at temperatures below 20 C. Safety considerations include the multiple halogen substituents' potential to release toxic fumes when heated and the thiazole ring's general toxicity. Proper protective measures should be taken during handling. APPLICATIONS: This compound primarily functions as a synthetic intermediate in the production of pharmaceuticals and specialty chemicals, where the dual halogenation provides versatile sites for cross-coupling and nucleophilic substitution reactions. In medicinal chemistry, it has been employed in developing antiviral agents targeting RNA viruses and has shown utility in creating agrochemicals with enhanced pesticidal activity. The bromochlorothiazole structure has also been explored in materials science for developing nonlinear optical materials, leveraging the polarizable halogen substituents to enhance optical properties. These applications are documented in publications from the Journal of Medicinal Chemistry and the Journal of Materials Chemistry C.
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