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2-amino-4-chlorothiazole-5-carbaldehyde; CAS No.: 76874-79-8; 2-amino-4-chlorothiazole-5-carbaldehyde. PROPERTIES: 2-amino-4-chlorothiazole-5-carbaldehyde appears as a white crystalline powder with molecular formula C4H3ClN2OS, possessing a molar mass of approximately 164.6 g/mol. It demonstrates limited water solubility but good solubility in methanol and ethyl acetate. Melting point observations typically fall between 100-104 C. Proper storage requires maintaining in tightly sealed containers at room temperature, protected from light and moisture. Safety precautions highlight potential to cause skin irritation and serious eye damage. Proper handling involves using protective eyewear and gloves, with accidental release requiring containment with inert materials. APPLICATIONS: This compound functions as a key intermediate in the synthesis of antibacterial agents, particularly those targeting gram-negative pathogens. Its amino group at position 2 and chloro substituent at position 4 enable selective alkylation reactions crucial for constructing target molecules. In medicinal chemistry research, it supports the development of kinase inhibitors through controlled derivatization pathways. The compound also contributes to materials science applications in fluorescent dye development for detecting biomolecules, with methodologies described in Journal of Medicinal Chemistry and chemical supplier catalogs, demonstrating its cross-disciplinary utility in antimicrobial therapy and analytical chemistry innovations.