4-methyl-1,2,3-thiadiazole-5-carboxylic acid
$200.00
CAS No.: 18212-21-0
Catalog No.: LT0133
Purity: 95%
MF: C4H4N2O2S
MW: 144.155
Storage: 2-8 degree Celsius
SMILES: CC=1N=NSC1C(=O)O
Catalog No.: LT0133
Purity: 95%
MF: C4H4N2O2S
MW: 144.155
Storage: 2-8 degree Celsius
SMILES: CC=1N=NSC1C(=O)O
CAS NO.: 18212-21-0;4-methyl-1,2,3-thiadiazole-5-carboxylic acid. PROPERTIES: This methyl-substituted thiadiazole presents as a white crystalline solid with a molecular weight of approximately 153.2 g/mol. The 4-methyl-1,2,3-thiadiazole-5-carboxylic acid combines a thiadiazole heterocycle with a carboxylic acid group. It exhibits limited aqueous solubility until pH < 4 but dissolves well in DMSO and DMF. Stability characterization reveals vulnerability to acid-catalyzed ring-opening and base-promoted decarboxylation, necessitating storage at 2-8 degree Celsius in sealed glass containers. Handlers should use powder hoods with HEPA filtration and wear cut-resistant gloves during handling. Skin contact may cause localized edema requiring corticosteroid application. Inhalation may induce respiratory alkalosis; treatment includes humidified oxygen administration. Eye exposure requires chelation inhibitors and ophthalmology evaluation. Waste should be hydrolyzed with dilute acid prior to disposal. APPLICATIONS: The 4-methyl-1,2,3-thiadiazole-5-carboxylic acid serves as a key intermediate in the synthesis of various pharmaceuticals. Its thiadiazole framework provides opportunities for directed metalation and cross-coupling reactions. Research teams utilize this compound as a starting material for creating kinase inhibitors and serotonin receptor modulators. The methyl substituent enhances metabolic resistance in resulting drug candidates. Additionally, it serves as a building block for creating agrochemical intermediates (excluding agricultural applications) and fluorescent probes with enhanced photostability.
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