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2-methyl-2H-tetrazol-5-amine; CAS No.: 6154-04-7; 2-methyl-2H-tetrazol-5-amine. PROPERTIES: This colorless to white crystalline powder has a molecular formula of C2H4N4 and a molecular weight of approximately 84.07 g/mol. It demonstrates moderate solubility in water and polar organic solvents. The compound is hygroscopic and should be stored in a desiccator at room temperature, protected from moisture. Thermal analysis shows decomposition above 150 C with evolution of nitrogen gas. Safety guidelines recommend using P100 respirators, nitrile gloves, and protective eyewear. In case of accidental ingestion, rinse mouth and seek immediate medical advice. Avoid release to the environment as tetrazole derivatives may affect aquatic organisms. APPLICATIONS: 2-methyl-2H-tetrazol-5-amine functions as a key building block in agrochemical and pharmaceutical formulations. Its tetrazole core provides bioisosteric replacement opportunities in drug discovery, enhancing metabolic stability and binding affinity. Patents from major pharmaceutical companies reference its use in angiotensin receptor blocker synthesis. The methyl substituent at position 2 offers steric and electronic advantages in asymmetric syntheses. Analytical laboratories employ it as a standard for HPLC method development and validation. In materials science, it serves as a monomer for polymeric materials with potential applications in sensor technologies. A recent study in Organic Process Research & Development illustrates its utility in click chemistry reactions, expanding its synthetic applications beyond traditional domains.