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(trans)-tetrahydrofuran-3,4-dicarboxylic acid; CAS No.: 1903836-65-6; (trans)-tetrahydrofuran-3,4-dicarboxylic acid. PROPERTIES: (Trans)-tetrahydrofuran-3,4-dicarboxylic acid presents as a white crystalline powder with a characteristic dicarboxylic acid odor. The compound demonstrates zwitterionic character at physiological pH and shows good solubility in basic aqueous solutions. It exhibits typical acid hydrolysis behavior when esterified. Recommended storage involves maintaining in tightly sealed containers at room temperature. Safety protocols recommend avoiding dust inhalation and providing local exhaust ventilation as per ACGIH threshold limit values for organic acids. APPLICATIONS: (Trans)-tetrahydrofuran-3,4-dicarboxylic acid serves as an intermediate in the synthesis of prostaglandin analogs documented in inflammatory disorder research. Its tetrahydrofuran-dicarboxylic acid framework enables formation of various bioactive esters useful in improving bioavailability as reported in pharmaceutical formulation journals. Furthermore, the compound contributes to synthesis of fluorescent sensors for metal ion detection described in analytical chemistry innovations.