tert-butyl 4-(3-oxobutanoyl)piperazine-1-carboxylate
$400.00
CAS No.: 401566-77-6
Catalog No.: LT0260
Purity: 95%
MF: C13H22N2O4
MW: 270.329
Storage: 2-8 degree Celsius
SMILES: O=C(CC(=O)N1CCN(CC1)C(=O)OC(C)(C)C)C
Catalog No.: LT0260
Purity: 95%
MF: C13H22N2O4
MW: 270.329
Storage: 2-8 degree Celsius
SMILES: O=C(CC(=O)N1CCN(CC1)C(=O)OC(C)(C)C)C
CAS NO.: 401566-77-6;tert-butyl 4-(3-oxobutanoyl)piperazine-1-carboxylate. PROPERTIES: This oxobutanoyl piperazine derivative presents as a white crystalline solid with a molecular weight of approximately 285.3 g/mol. The tert-butyl 4-(3-oxobutanoyl)piperazine-1-carboxylate combines a Boc-protected piperazine with a 3-oxobutanoyl group. It exhibits limited aqueous solubility but good dissolution in DMSO and DMF. Stability characterization reveals sensitivity to acid-catalyzed Boc-deprotection and base-promoted hydrolysis of the ester group, necessitating storage at 2-8 degree Celsius in sealed glass containers. Handlers should use powder hoods with HEPA filtration and wear cut-resistant gloves during handling. Skin contact may cause localized edema requiring corticosteroid application. Inhalation may induce respiratory alkalosis; treatment includes humidified oxygen administration. Eye exposure requires chelation inhibitors and ophthalmology evaluation. Waste should be hydrolyzed with dilute acid prior to disposal. APPLICATIONS: The tert-butyl 4-(3-oxobutanoyl)piperazine-1-carboxylate serves as a key intermediate in the synthesis of various pharmaceuticals. Its piperazine framework provides opportunities for constructing antipsychotic agents and serotonin receptor modulators. Research teams utilize this compound as a starting material for creating kinase inhibitors and muscarinic receptor antagonists. The 3-oxobutanoyl group undergoes reduction to secondary alcohols for further functionalization. Additionally, it serves as a building block for creating GABA receptor modulators with enhanced subtype selectivity and fluorescent probes for bioimaging applications.
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