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thiophene-2-sulfonamide
$350.00
CAS No.: 6339-87-3
Catalog No.: 196099
Purity: 95%
MF: C4H5NO2S2
MW: 163.223
Storage: 2-8 degree Celsius
SMILES: S1C(=CC=C1)S(=O)(=O)N
Catalog No.: 196099
Purity: 95%
MF: C4H5NO2S2
MW: 163.223
Storage: 2-8 degree Celsius
SMILES: S1C(=CC=C1)S(=O)(=O)N
thiophene-2-sulfonamide; CAS No.: 6339-87-3; thiophene-2-sulfonamide. PROPERTIES: Thiophene-2-sulfonamide is a crystalline solid with a molecular weight of approximately 173.2 g/mol. It has a melting point between 170-175 C. The compound is moderately soluble in polar organic solvents like dimethylformamide and dimethyl sulfoxide but is practically insoluble in water. The sulfonamide group imparts significant hydrogen bonding capabilities. For proper storage, keep in a tightly sealed container at room temperature away from heat and moisture. Safety: This compound may cause skin corrosion and serious eye damage. In case of accidental ingestion, rinse mouth immediately and seek medical advice. Use personal protective equipment including safety glasses and laboratory coats. APPLICATIONS: In pharmaceutical research, thiophene-2-sulfonamide serves as a building block for creating antimicrobial agents. The sulfonamide group inhibits dihydropteroate synthase, a key enzyme in bacterial folate synthesis. In organic synthesis, it is used as a starting material for creating heterocyclic compounds via nucleophilic substitution reactions. The thiophene ring provides structural features that enhance binding to biological targets. In materials science, derivatives of this compound are explored for creating ion-selective electrodes. The combination of the thiophene ring and the sulfonamide group creates a scaffold that selectively binds certain cations. These applications are documented in medicinal chemistry journals and materials science research articles.
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