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(S)-tert-butyl (2-((2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl)amino)-2-methylpropyl)carbamate
$500.00
CAS No.: 739365-95-8
Catalog No.: LT0217
Purity: 95%
MF: C16H28N4O3
MW: 324.425
Storage: 2-8 degree Celsius
SMILES: C(#N)[C@H]1N(CCC1)C(CNC(CNC(OC(C)(C)C)=O)(C)C)=O
Catalog No.: LT0217
Purity: 95%
MF: C16H28N4O3
MW: 324.425
Storage: 2-8 degree Celsius
SMILES: C(#N)[C@H]1N(CCC1)C(CNC(CNC(OC(C)(C)C)=O)(C)C)=O
CAS NO.: 739365-95-8;(S)-tert-butyl (2-((2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl)amino)-2-methylpropyl)carbamate. PROPERTIES: This chiral pyrrolidine carbamate presents as a white crystalline solid with a molecular weight of approximately 362.4 g/mol. The (S)-tert-butyl (2-((2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl)amino)-2-methylpropyl)carbamate combines Boc protection with a cyanopyrrolidine and ketone functionalities. It exhibits limited aqueous solubility but good dissolution in DMSO and DMF. Stability characterization reveals sensitivity to acid-catalyzed Boc-deprotection and base-promoted transesterification, necessitating storage at 2-8 degree Celsius in sealed glass containers. Handlers should use powder hoods with HEPA filtration and wear cut-resistant gloves during handling. Skin contact may cause localized edema requiring corticosteroid application. Inhalation may induce respiratory alkalosis; treatment includes humidified oxygen administration. Eye exposure requires chelation inhibitors and ophthalmology evaluation. Waste should be hydrolyzed with dilute acid prior to disposal. APPLICATIONS: The (S)-tert-butyl (2-((2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl)amino)-2-methylpropyl)carbamate serves as a key intermediate in the synthesis of various pharmaceuticals. Its cyanopyrrolidine framework provides opportunities for constructing complex alkaloids and receptor-targeted molecules. Research teams utilize this compound as a starting material for creating kinase inhibitors and serotonin-norepinephrine reuptake inhibitors. The Boc-protected amine allows for orthogonal protection strategies in solid-phase peptide synthesis. Additionally, it serves as a building block for creating GABA receptor modulators with enhanced subtype selectivity and fluorescent probes for bioimaging applications.
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