2-chloro-3-hydrazinylquinoxaline
$200.00
CAS No.: 51347-93-4
Catalog No.: 197616
Purity: 95%
MF: C8H7ClN4
MW: 194.625
Storage: 2-8 degree Celsius
SMILES: ClC1=NC2=CC=CC=C2N=C1NN
Catalog No.: 197616
Purity: 95%
MF: C8H7ClN4
MW: 194.625
Storage: 2-8 degree Celsius
SMILES: ClC1=NC2=CC=CC=C2N=C1NN
2-chloro-3-hydrazinylquinoxaline; CAS No.: 51347-93-4;2-chloro-3-hydrazinylquinoxaline. PROPERTIES: 2-chloro-3-hydrazinylquinoxaline is a heterocyclic compound with a molecular weight of 193.66 g/mol. This yellowish crystalline solid has a melting point ranging from 198-201 C. The quinoxaline ring system features a chloro substituent at position 2 and a hydrazinyl group at position 3. It exhibits limited solubility in common organic solvents such as dimethylformamide and DMSO but is practically insoluble in water. The compound is hygroscopic and should be stored in tightly sealed containers under dry conditions, preferably at temperatures below 25 C. Safety considerations include the hydrazine group's high reactivity and toxicity, as well as the chlorinated aromatic structure's general hazards. Proper protective equipment and ventilation should be utilized during handling. APPLICATIONS: This compound primarily serves as a key intermediate in the synthesis of antitubercular and antiviral agents, where the hydrazinyl group participates in condensation reactions to form bioactive heterocycles. In pharmaceutical research, it has been employed in developing non-nucleoside reverse transcriptase inhibitors for HIV treatment and has shown activity against multidrug-resistant tuberculosis strains. The quinoxaline scaffold has also been explored in the development of nitric oxide donors for cardiovascular applications, leveraging the hydrazine group's ability to form diazo compounds. These applications are supported by research published in the European Journal of Medicinal Chemistry and the Journal of Medicinal Chemistry.
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