8-chloroquinolin-7-amine
$365.00
CAS No.: 1379334-91-4
Catalog No.: 192369
Purity: 95%
MF: C9H7ClN2
MW: 178.622
Storage: 2-8 degree Celsius
SMILES: ClC=1C(=CC=C2C=CC=NC12)N
Catalog No.: 192369
Purity: 95%
MF: C9H7ClN2
MW: 178.622
Storage: 2-8 degree Celsius
SMILES: ClC=1C(=CC=C2C=CC=NC12)N
8-chloroquinolin-7-amine; CAS No.: 1379334-91-4; 8-chloroquinolin-7-amine. PROPERTIES: 8-chloroquinolin-7-amine is a crystalline compound with molecular formula C9H6ClNN2. It has a melting point between 145-150 C and exhibits moderate solubility in ethanol and methanol. The compound should be stored in a tightly sealed container at room temperature away from strong oxidizing agents. Safety precautions include avoiding contact with eyes and skin due to its potential to cause serious eye damage and skin irritation. APPLICATIONS: This chlorinated quinoline amine is employed in the development of dual kinase/HDAC inhibitors. The amine group facilitates binding to the catalytic site of kinases while the chlorine substituent enhances HDAC inhibitory activity as described in cancer research literature. In chemical biology, 8-chloroquinolin-7-amine serves as a tag for bioorthogonal labeling. According to biochemical journals, the quinoline scaffold provides a fluorescent signal while the amine group enables conjugation with azide-containing biomolecules via click chemistry.
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