7-bromoquinolin-8-amine
$350.00
CAS No.: 85656-65-1
Catalog No.: 192213
Purity: 95%
MF: C9H7BrN2
MW: 223.073
Storage: 2-8 degree Celsius
SMILES: BrC1=CC=C2C=CC=NC2=C1N
Catalog No.: 192213
Purity: 95%
MF: C9H7BrN2
MW: 223.073
Storage: 2-8 degree Celsius
SMILES: BrC1=CC=C2C=CC=NC2=C1N
7-bromoquinolin-8-amine; CAS No.: 85656-65-1; 7-bromoquinolin-8-amine. PROPERTIES: 7-bromoquinolin-8-amine is a light-sensitive compound appearing as a brownish solid. It has a molecular weight of 237.08 g/mol and a melting point between 160-165 C. The compound is sparingly soluble in water but dissolves in polar aprotic solvents. Proper storage requires amber glassware, protection from light, and temperatures below 20 C. Safety precautions include avoiding contact with aqueous solutions and using spark-proof tools due to its flammability and potential to cause skin irritation. APPLICATIONS: This brominated quinoline amine is utilized in the synthesis of dual kinase/HDAC inhibitors. According to cancer research literature, the amine group facilitates binding to the catalytic site of kinases while the bromine substituent enhances HDAC inhibitory activity. In chemical biology, 7-bromoquinolin-8-amine serves as a tag for bioorthogonal labeling. As reported in biochemical journals, the quinoline scaffold provides a fluorescent signal while the amine group enables conjugation with azide-containing biomolecules via click chemistry.
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