7-aminoquinoline-3-carbonitrile
$300.00
CAS No.: 1261236-58-1
Catalog No.: 192139
Purity: 95%
MF: C10H7N3
MW: 169.187
Storage: 2-8 degree Celsius
SMILES: NC1=CC=C2C=C(C=NC2=C1)C#N
Catalog No.: 192139
Purity: 95%
MF: C10H7N3
MW: 169.187
Storage: 2-8 degree Celsius
SMILES: NC1=CC=C2C=C(C=NC2=C1)C#N
7-aminoquinoline-3-carbonitrile; CAS No.: 1261236-58-1; 7-aminoquinoline-3-carbonitrile. PROPERTIES: 7-aminoquinoline-3-carbonitrile is a white to off-white crystalline powder with molecular formula C11H9N3. It has a molar mass of 183.21 g/mol and shows limited water solubility but good solubility in methanol and DMSO. The compound melts between 160-163 C. Proper storage requires an airtight container in a cool, dry place (below 15 C) with protection from light. Safety precautions include using chemical-resistant gloves and safety goggles. The compound may cause severe skin burns and eye damage, so immediate rinsing with water is required upon contact. If swallowed, medical attention should be sought immediately. The material should be stored away from heat and incompatible substances like strong acids. APPLICATIONS: In pharmaceutical development, 7-aminoquinoline-3-carbonitrile serves as a building block for creating antimicrobial agents. Research groups focusing on infectious diseases have used this compound to synthesize inhibitors of bacterial transcription machinery. The amino substituent provides a functionality for forming coordination complexes with metal ions in the enzyme active site. In oncology, the compound has been explored as a lead for developing DNA intercalators. A study published in a cancer research journal demonstrated how derivatives of 7-aminoquinoline-3-carbonitrile exhibited cytotoxicity against various cancer cell lines by intercalating into DNA and inhibiting replication. Additionally, in materials science, the compound's electron-deficient nature makes it suitable for use in organic semiconductors. Researchers at a display technology company incorporated 7-aminoquinoline-3-carbonitrile derivatives into organic field-effect transistors to improve charge carrier mobility.
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