5-bromo-6-fluoroquinoline
$300.00
CAS No.: 107224-21-5
Catalog No.: 192349
Purity: 95%
MF: C9H5BrFN
MW: 226.048
Storage: 2-8 degree Celsius
SMILES: BrC1=C2C=CC=NC2=CC=C1F
Catalog No.: 192349
Purity: 95%
MF: C9H5BrFN
MW: 226.048
Storage: 2-8 degree Celsius
SMILES: BrC1=C2C=CC=NC2=CC=C1F
5-bromo-6-fluoroquinoline; CAS No.: 107224-21-5; 5-bromo-6-fluoroquinoline. PROPERTIES: 5-bromo-6-fluoroquinoline is a crystalline powder with molecular formula C9H5BrFNN. It has a melting point of approximately 170-175 C and exhibits moderate solubility in ethanol and methanol. The compound should be stored in a tightly sealed container at room temperature away from strong oxidizing agents. Safety precautions include avoiding contact with eyes and skin due to its potential to cause serious eye damage and skin irritation. APPLICATIONS: This brominated, fluorinated quinoline is employed in the development of dual kinase/HDAC inhibitors. The amine group facilitates binding to the catalytic site of kinases while the bromine substituent enhances HDAC inhibitory activity as described in cancer research literature. In chemical biology, 5-bromo-6-fluoroquinoline serves as a tag for bioorthogonal labeling. According to biochemical journals, the quinoline scaffold provides a fluorescent signal while the bromine group enables conjugation with azide-containing biomolecules via click chemistry.
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