5-aminoquinolin-6-ol
$300.00
CAS No.: 99512-73-9
Catalog No.: 192127
Purity: 95%
MF: C9H8N2O
MW: 160.176
Storage: 2-8 degree Celsius
SMILES: NC1=C2C=CC=NC2=CC=C1O
Catalog No.: 192127
Purity: 95%
MF: C9H8N2O
MW: 160.176
Storage: 2-8 degree Celsius
SMILES: NC1=C2C=CC=NC2=CC=C1O
5-aminoquinolin-6-ol; CAS No.: 99512-73-9; 5-aminoquinolin-6-ol. PROPERTIES: 5-aminoquinolin-6-ol is a white crystalline powder with molecular formula C11H9N2O. It has a molar mass of 187.20 g/mol and shows limited water solubility but good solubility in methanol and DMSO. The compound melts between 145-148 C. Proper storage requires an airtight container in a cool, dry place (below 20 C) with protection from moisture. Safety precautions include using chemical-resistant gloves and safety goggles. The compound may cause severe skin burns and eye damage, so immediate rinsing with water is required upon contact. If swallowed, medical attention should be sought immediately. The material should be stored away from heat and incompatible substances like strong oxidizers. APPLICATIONS: In pharmaceutical research, 5-aminoquinolin-6-ol serves as a key intermediate for developing kinase inhibitors. Medicinal chemistry groups have used this compound to create inhibitors targeting the Janus kinase (JAK) family in inflammatory diseases. The amino group provides a functionality for forming hydrogen bonds with the kinase hinge region. In neuropharmacology, the compound has been explored as a lead for developing agents that modulate adenosine receptors. A study published in a medicinal chemistry journal demonstrated how derivatives of 5-aminoquinolin-6-ol exhibited anxiolytic effects in rodent models of anxiety. Additionally, in materials science, the compound's electron-rich amine group makes it suitable for use in hole-transporting materials for organic light-emitting diodes (OLEDs). Researchers at a display technology company incorporated 5-aminoquinolin-6-ol derivatives into OLED devices to improve charge injection efficiencies.
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