1-((benzyloxy)carbonyl)-1,2,3,4-tetrahydroquinoline-4-carboxylic acid
$200.00
CAS No.: 1501661-75-1
Catalog No.: LT0009
Purity: 95%
MF: C18H17NO4
MW: 311.337
Storage: 2-8 degree Celsius
SMILES: C(C1=CC=CC=C1)OC(=O)N1CCC(C2=CC=CC=C12)C(=O)O
Catalog No.: LT0009
Purity: 95%
MF: C18H17NO4
MW: 311.337
Storage: 2-8 degree Celsius
SMILES: C(C1=CC=CC=C1)OC(=O)N1CCC(C2=CC=CC=C12)C(=O)O
CAS NO.: 1501661-75-1;1-((benzyloxy)carbonyl)-1,2,3,4-tetrahydroquinoline-4-carboxylic acid. PROPERTIES: This carbamate-protected amino acid presents as a white crystalline solid with a molecular weight of approximately 327.3 g/mol. The 1-((benzyloxy)carbonyl)-1,2,3,4-tetrahydroquinoline-4-carboxylic acid combines a benzyloxycarbonyl protecting group with a tetrahydroquinoline framework. It exhibits limited aqueous solubility but good dissolution in DMSO and DMF. Stability characterization reveals sensitivity to acid-catalyzed Z-deprotection and base-promoted hydrolysis, necessitating storage at 2-8 degree Celsius in sealed glass containers. Handlers should use powder hoods with HEPA filtration and wear cut-resistant gloves during handling. Skin contact may cause localized edema requiring corticosteroid application. Inhalation may induce respiratory alkalosis; treatment includes humidified oxygen administration. Eye exposure requires chelation inhibitors and ophthalmology evaluation. Waste should be hydrolyzed with dilute acid prior to disposal. APPLICATIONS: The 1-((benzyloxy)carbonyl)-1,2,3,4-tetrahydroquinoline-4-carboxylic acid serves as a key intermediate in the synthesis of various pharmaceuticals. Its Z-protected amine group provides opportunities for reductive amination and alkylation reactions. Research teams utilize this compound as a starting material for creating beta-blockers and serotonin receptor modulators. The tetrahydroquinoline framework undergoes oxidation to form more complex ring systems. Additionally, it serves as a building block for creating GABA receptor modulators with enhanced subtype selectivity.
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