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7-bromo-2-methylquinazoline; CAS No.: 552331-87-0; This bromoquinazoline highlights our building blocks for drug discovery in EGFR inhibition. The 7-bromo-2-methyl substitution enables covalent binding to C797 residue. Our Gould-Jacobs cyclization achieves high yield. The product facilitates development of fourth-generation TKIs targeting osimertinib-resistant mutations.