4-chloro-6-iodo-7-methoxyquinazoline
$300.00
CAS No.: 1172851-61-4
Catalog No.: TQ0109
Purity: 95%
MF: C9H6ClIN2O
MW: 320.517
Storage: 2-8 degree Celsius
SMILES: ClC1=NC=NC2=CC(=C(C=C12)I)OC
Catalog No.: TQ0109
Purity: 95%
MF: C9H6ClIN2O
MW: 320.517
Storage: 2-8 degree Celsius
SMILES: ClC1=NC=NC2=CC(=C(C=C12)I)OC
CAS NO.: 1172851-61-4;4-chloro-6-iodo-7-methoxyquinazoline. PROPERTIES: This chloroiodomethoxyquinazoline presents as a white crystalline solid with a molecular weight of approximately 333.5 g/mol. The 4-chloro-6-iodo-7-methoxyquinazoline combines chloro, iodo, and methoxy substituents on a quinazoline ring. It exhibits limited aqueous solubility but good dissolution in polar aprotic solvents like DMSO and THF. Stability characterization reveals sensitivity to nucleophilic aromatic substitution and base-promoted deprotonation, necessitating storage at 2-8 degree Celsius in sealed glass containers. Handlers should use powder hoods with HEPA filtration and wear cut-resistant gloves during handling. Skin contact may cause localized edema requiring corticosteroid application. Inhalation may induce respiratory alkalosis; treatment includes humidified oxygen administration. Eye exposure requires chelation inhibitors and ophthalmology evaluation. Waste should be hydrolyzed with dilute acid prior to disposal. APPLICATIONS: The 4-chloro-6-iodo-7-methoxyquinazoline serves as a key intermediate in the synthesis of various pharmaceuticals. Its quinazoline framework provides opportunities for constructing kinase inhibitors and EGFR modulators. Research teams utilize this compound as a starting material for creating anticancer agents and antiproliferative drugs. The iodine substituent serves as a potent electrophilic handle for cross-coupling reactions. Additionally, it undergoes Buchwald-Hartwig amination for constructing anilinic systems. The compound's unique substitution pattern makes it valuable in the development of fluorescent imaging agents and contrast media.
Reviews
Write Your Own Review