4-chloro-2-cyclopropyl-6-fluoroquinazoline
$275.00
CAS No.: 1695621-65-8
Catalog No.: 192511
Purity: 95%
MF: C11H8ClFN2
MW: 222.65
Storage: 2-8 degree Celsius
SMILES: ClC1=NC(=NC2=CC=C(C=C12)F)C1CC1
Catalog No.: 192511
Purity: 95%
MF: C11H8ClFN2
MW: 222.65
Storage: 2-8 degree Celsius
SMILES: ClC1=NC(=NC2=CC=C(C=C12)F)C1CC1
4-chloro-2-cyclopropyl-6-fluoroquinazoline; CAS No.: 1695621-65-8; 4-chloro-2-cyclopropyl-6-fluoroquinazoline. PROPERTIES: 4-chloro-2-cyclopropyl-6-fluoroquinazoline is a crystalline compound with molecular formula C11H8ClFN2. It has a melting point between 170-175 C and exhibits limited solubility in common organic solvents. The compound is light-sensitive and should be stored in amber glassware at 2-8 C. Safety precautions include wearing protective clothing due to its potential to cause skin burns and using explosion-proof ventilation due to its flammable nature. APPLICATIONS: This chlorinated, fluorinated, cyclopropyl-substituted quinazoline is employed in the development of kinase inhibitors. The cyclopropyl group provides unique binding affinity as described in cancer research literature. In medicinal chemistry, 4-chloro-2-cyclopropyl-6-fluoroquinazoline serves as a key intermediate for creating central nervous system agents. According to pharmaceutical patents, the fluorine substituent enhances blood-brain barrier penetration while the cyclopropyl and chlorine groups offer metabolic stability.
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