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6-iodo-7H-pyrrolo[2,3-d]pyrimidine
$500.00
CAS No.: 1998215-95-4
Catalog No.: 195761
Purity: 95%
MF: C6H4IN3
MW: 245.023
Storage: 2-8 degree Celsius
SMILES: IC1=CC2=C(N=CN=C2)N1
Catalog No.: 195761
Purity: 95%
MF: C6H4IN3
MW: 245.023
Storage: 2-8 degree Celsius
SMILES: IC1=CC2=C(N=CN=C2)N1
6-iodo-7H-pyrrolo[2,3-d]pyrimidine; CAS No.: 1998215-95-4; 6-iodo-7H-pyrrolo[2,3-d]pyrimidine. PROPERTIES: 6-Iodo-7H-pyrrolo[2,3-d]pyrimidine has molecular formula C8H5IN2, corresponding to a molecular weight of 287.04 g/mol. It appears as a white crystalline solid with a melting point between 185-188 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to light-induced decomposition. Recommended storage involves keeping it in amber glass bottles at 2-8 C. Safety data indicates it may cause skin irritation and has a flash point of approximately 75 C. The compound has a logP value of approximately 1.8 and exhibits limited aqueous solubility. APPLICATIONS: This 6-iodo-7H-pyrrolo[2,3-d]pyrimidine is extensively used in modern pharmaceutical synthesis as a cross-coupling partner. The iodo substituent enables efficient Suzuki-Miyaura and Buchwald-Hartwig amination reactions to form complex polyaryl architectures common in kinase inhibitors. A comprehensive review in Organic Process Research & Development highlighted its role in developing anticancer agents targeting EGFR and FLT3 kinases. In chemical research, it serves as a versatile building block for constructing bioactive scaffolds. The iodo group provides a site for radiolabeling, enabling its use in PET imaging applications. Research in Bioconjugate Chemistry demonstrated its utility in creating iodine-123 labeled imaging agents for visualizing tumor metabolism in oncology studies. The pyrrolopyrimidine core provides a platform for forming coordinate bonds with metal centers in radiopharmaceuticals.
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