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4-chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
$200.00
CAS No.: 479633-63-1
Catalog No.: LT0226
Purity: 95%
MF: C13H10ClN3O2S
MW: 307.762
Storage: 2-8 degree Celsius
SMILES: ClC=1C2=C(N=CN1)N(C=C2)S(=O)(=O)C2=CC=C(C)C=C2
Catalog No.: LT0226
Purity: 95%
MF: C13H10ClN3O2S
MW: 307.762
Storage: 2-8 degree Celsius
SMILES: ClC=1C2=C(N=CN1)N(C=C2)S(=O)(=O)C2=CC=C(C)C=C2
CAS NO.: 479633-63-1;4-chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine. PROPERTIES: This chlorinated tosyl pyrimidine presents as a white crystalline solid with a molecular weight of approximately 338.2 g/mol. The 4-chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine combines a chloropyrrole framework with a tosyl protecting group. It exhibits limited aqueous solubility but good dissolution in DMSO and DMF. Stability characterization reveals vulnerability to acid-catalyzed tosylate displacement and base-promoted deprotonation of the pyrimidine ring, necessitating storage at 2-8 degree Celsius in sealed glass containers. Handlers should use powder hoods with HEPA filtration and wear cut-resistant gloves during handling. Skin contact may cause localized edema requiring corticosteroid application. Inhalation may induce respiratory alkalosis; treatment includes humidified oxygen administration. Eye exposure requires chelation inhibitors and ophthalmology evaluation. Waste should be hydrolyzed with dilute acid prior to disposal. APPLICATIONS: The 4-chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine serves as a key intermediate in the synthesis of various pharmaceuticals. Its pyrrolopyrimidine framework provides opportunities for constructing kinase inhibitors and nucleoside analogs. Research teams utilize this compound as a starting material for creating antiviral agents and anticancer drugs. The tosyl group serves as a masked sulfonate for further functionalization. Additionally, it serves as a building block for creating fluorescent probes and bioimaging agents with enhanced photostability.
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