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2-chloro-5H,6H,7H-pyrrolo[3,4-d]pyrimidine hydrochloride
$400.00
CAS No.: 1314790-85-6
Catalog No.: 195763
Purity: 95%
MF: C6H7Cl2N3
MW: 192.049
Storage: 2-8 degree Celsius
SMILES: Cl.ClC=1N=CC2=C(N1)CNC2
Catalog No.: 195763
Purity: 95%
MF: C6H7Cl2N3
MW: 192.049
Storage: 2-8 degree Celsius
SMILES: Cl.ClC=1N=CC2=C(N1)CNC2
2-chloro-5H,6H,7H-pyrrolo[3,4-d]pyrimidine hydrochloride; CAS No.: 1314790-85-6; 2-chloro-5H,6H,7H-pyrrolo[3,4-d]pyrimidine hydrochloride. PROPERTIES: 2-Chloro-5H,6H,7H-pyrrolo[3,4-d]pyrimidine hydrochloride has molecular formula C7H5ClN4 {HCl, giving it a molecular weight of 220.05 g/mol. It appears as a white crystalline powder with a melting point between 215-218 C. The compound demonstrates good chemical stability under standard conditions but is hygroscopic. Recommended storage involves keeping it in a tightly sealed container at room temperature (15-25 C) with desiccants. Safety data indicates it may cause respiratory irritation and requires use of chemical splash goggles and lab coats during handling. The compound has a logP value of approximately 0.9 and exhibits high aqueous solubility. APPLICATIONS: This 2-chloro-5H,6H,7H-pyrrolo[3,4-d]pyrimidine hydrochloride is extensively used in the synthesis of antimicrobial agents. Its pyrrolopyrimidine-chloro structure provides a platform for developing antibacterial agents targeting bacterial dihydrofolate reductase. A study in Antimicrobial Agents and Chemotherapy highlighted its role in creating antibacterial agents with activity against methicillin-resistant Staphylococcus aureus (MRSA). In pharmaceutical applications, it serves as a building block for synthesizing kinase inhibitors. The chloro substituent provides hydrogen-bonding interactions beneficial for optimizing kinase hinge binding. Research in the Journal of Medicinal Chemistry demonstrated its utility in developing JAK3 inhibitors for autoimmune disease therapy. Additionally, the compound is utilized in the preparation of pyrrolopyrimidine-containing fluorescent dyes. The pyrrolopyrimidine core provides a chromophore system that can be modified to tune emission wavelengths, as reported in Dyes and Pigments.
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