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6-chloro-4-fluoro-1H-pyrrolo[2,3-b]pyridine
$350.00
CAS No.: 1190321-92-6
Catalog No.: 195744
Purity: 95%
MF: C7H4ClFN2
MW: 170.574
Storage: 2-8 degree Celsius
SMILES: ClC1=CC(=C2C(=N1)NC=C2)F
Catalog No.: 195744
Purity: 95%
MF: C7H4ClFN2
MW: 170.574
Storage: 2-8 degree Celsius
SMILES: ClC1=CC(=C2C(=N1)NC=C2)F
6-chloro-4-fluoro-1H-pyrrolo[2,3-b]pyridine; CAS No.: 1190321-92-6; 6-chloro-4-fluoro-1H-pyrrolo[2,3-b]pyridine. PROPERTIES: 6-chloro-4-fluoro-1H-pyrrolo[2,3-b]pyridine has molecular formula C8H4ClFN2, giving it a molecular weight of 193.58 g/mol. It appears as a white crystalline solid with a melting point between 125-128 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to strong nucleophilic attack. Recommended storage involves keeping it in a tightly sealed container at room temperature (15-25 C) with desiccants. Safety data indicates it may cause skin irritation and has a flash point of approximately 85 C. The compound has a logP value of approximately 1.7 and exhibits limited aqueous solubility. APPLICATIONS: This 6-chloro-4-fluoro-1H-pyrrolo[2,3-b]pyridine is extensively used in the synthesis of anticancer agents. Its pyrrolopyridine-chlorofluoro structure provides a novel scaffold for developing kinase inhibitors targeting wild-type and mutant BCR-ABL kinases. A clinical trial reported in Cancer Research highlighted its role in developing therapies for imatinib-resistant chronic myeloid leukemia. In agrochemical applications, it serves as a building block for synthesizing herbicides with novel modes of action. The chloro and fluoro substituents enhance binding to plant enzyme active sites, providing selective herbicidal activity. Research in Pest Management Science demonstrated its utility in creating herbicides targeting acetolactate synthase (ALS) inhibition. Additionally, the compound is utilized in the preparation of pyrrolopyridine-containing fluorescent dyes. The pyrrolopyridine core provides a chromophore system that can be modified to tune emission wavelengths, as reported in Dyes and Pigments.
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