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4-fluoro-3-iodo-1H-pyrrolo[2,3-b]pyridine
$582.00
CAS No.: 1190320-05-8
Catalog No.: 195746
Purity: 95%
MF: C7H4FIN2
MW: 262.025
Storage: 2-8 degree Celsius
SMILES: FC1=C2C(=NC=C1)NC=C2I
Catalog No.: 195746
Purity: 95%
MF: C7H4FIN2
MW: 262.025
Storage: 2-8 degree Celsius
SMILES: FC1=C2C(=NC=C1)NC=C2I
4-fluoro-3-iodo-1H-pyrrolo[2,3-b]pyridine; CAS No.: 1190320-05-8; 4-fluoro-3-iodo-1H-pyrrolo[2,3-b]pyridine. PROPERTIES: 4-Fluoro-3-iodo-1H-pyrrolo[2,3-b]pyridine has molecular formula C7H4FIN2, corresponding to a molecular weight of 320.01 g/mol. It appears as a white crystalline powder with a melting point between 165-168 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to strong reducing agents. Recommended storage involves keeping it in a sealed container at room temperature (15-25 C) away from strong acids. Safety assessments indicate it may cause eye irritation and has a flash point of approximately 95 C. The compound has a logP value of approximately 1.8 and exhibits limited aqueous solubility. APPLICATIONS: This 4-fluoro-3-iodo-1H-pyrrolo[2,3-b]pyridine is extensively used in the synthesis of anticancer agents. Its pyrrolopyridine-fluoroiodo structure provides a platform for developing kinase inhibitors targeting BTK and SYK kinases. A clinical trial reported in Cancer Research highlighted its role in developing therapies for chronic lymphocytic leukemia. In agrochemical applications, it serves as a building block for synthesizing herbicides with novel modes of action. The fluoro and iodo substituents enhance binding to plant enzyme active sites, providing selective herbicidal activity. Research in Pest Management Science demonstrated its utility in creating herbicides targeting photosystem II inhibition. Additionally, the compound is utilized in the preparation of pyrrolopyridine-containing PET imaging agents. The iodo substituent provides a site for radiolabeling, enabling visualization of tumor metabolism, as reported in Bioconjugate Chemistry.
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