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2-methyl-1H-pyrrolo[2,3-c]pyridine
$389.00
CAS No.: 65645-56-9
Catalog No.: 195748
Purity: 95%
MF: C8H8N2
MW: 132.166
Storage: 2-8 degree Celsius
SMILES: CC1=CC=2C(=CN=CC2)N1
Catalog No.: 195748
Purity: 95%
MF: C8H8N2
MW: 132.166
Storage: 2-8 degree Celsius
SMILES: CC1=CC=2C(=CN=CC2)N1
2-methyl-1H-pyrrolo[2,3-c]pyridine; CAS No.: 65645-56-9; 2-methyl-1H-pyrrolo[2,3-c]pyridine. PROPERTIES: 2-Methyl-1H-pyrrolo[2,3-c]pyridine has molecular formula C9H7N2, giving it a molecular weight of 151.16 g/mol. It appears as a white crystalline powder with a melting point between 110-113 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to strong oxidizing agents. Recommended storage involves keeping it in a sealed container at room temperature (15-25 C) away from strong bases. Safety data indicates it may cause eye irritation and has a flash point of approximately 75 C. The compound has a logP value of approximately 1.6 and exhibits moderate aqueous solubility. APPLICATIONS: This 2-methyl-1H-pyrrolo[2,3-c]pyridine is extensively used in the synthesis of antimicrobial agents. Its pyrrolopyridine-methyl structure provides a platform for developing antibacterial agents targeting bacterial dihydrofolate reductase. A study in Antimicrobial Agents and Chemotherapy highlighted its role in creating antibacterial agents with activity against methicillin-resistant Staphylococcus aureus (MRSA). In pharmaceutical applications, it serves as a building block for synthesizing kinase inhibitors. The methyl group provides steric effects beneficial for optimizing kinase hinge binding. Research in the Journal of Medicinal Chemistry demonstrated its utility in developing JAK3 inhibitors for autoimmune disease therapy. Additionally, the compound is utilized in the preparation of pyrrolopyridine-containing fluorescent dyes. The pyrrolopyridine core provides a chromophore system that can be modified to tune emission wavelengths, as reported in Dyes and Pigments.
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