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2-(1H-pyrrolo[2,3-b]pyridin-3-yl)acetonitrile; CAS No.: 4414-87-3; ChemShuttle provides heterocycles like this pyrrolopyridine nitrile for JAK inhibitor development. The 3-acetonitrile group enables click chemistry modifications. Our Cadogan cyclization achieves efficient indolizine ring formation. This building block facilitates synthesis of covalent kinase inhibitors through targeted cysteine engagement.