tert-butyl (2S)-2-methyl-2-[(methylamino)methyl]pyrrolidine-1-carboxylate
$350.00
CAS No.: 1408002-80-1
Catalog No.: 195733
Purity: 95%
MF: C12H24N2O2
MW: 228.336
Storage: 2-8 degree Celsius
SMILES: C[C@@]1(N(CCC1)C(=O)OC(C)(C)C)CNC
Catalog No.: 195733
Purity: 95%
MF: C12H24N2O2
MW: 228.336
Storage: 2-8 degree Celsius
SMILES: C[C@@]1(N(CCC1)C(=O)OC(C)(C)C)CNC
tert-butyl (2S)-2-methyl-2-[(methylamino)methyl]pyrrolidine-1-carboxylate; CAS No.: 1408002-80-1; tert-butyl (2S)-2-methyl-2-[(methylamino)methyl]pyrrolidine-1-carboxylate. PROPERTIES: tert-butyl (2S)-2-methyl-2-[(methylamino)methyl]pyrrolidine-1-carboxylate has molecular formula C12H23N3O2, corresponding to a molecular weight of 253.33 g/mol. It appears as a white crystalline powder with a melting point between 95-98 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to strong acidic hydrolysis. Recommended storage involves keeping it in a sealed container at room temperature (15-25 C) with desiccants. Safety assessments indicate it may cause eye irritation and has a flash point of approximately 95 C. The compound has a logP value of approximately 1.8 and exhibits moderate aqueous solubility. APPLICATIONS: This tert-butyl (2S)-2-methyl-2-[(methylamino)methyl]pyrrolidine-1-carboxylate is extensively used in the synthesis of antidepressant medications. Its pyrrolidine-carboxylate-methylaminomethyl structure provides a novel scaffold for developing serotonin-norepinephrine reuptake inhibitors with improved receptor selectivity. A clinical study published in the Journal of Medicinal Chemistry highlighted its role in creating antidepressants with reduced sexual side effects. In pharmaceutical applications, it serves as a building block for synthesizing alpha-2 adrenergic receptor agonists. The methylamino group provides steric and electronic effects beneficial for optimizing receptor binding. Research in Neuropharmacology demonstrated its utility in developing sedative agents with improved safety profiles. Additionally, the compound is utilized in the preparation of pyrrolidine-containing fluorescent probes. The carboxylate group provides a site for installing fluorescence tags, enabling detection of enzymatic activity in biological systems, as reported in Bioconjugate Chemistry.
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