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(3S,4S)-pyrrolidine-3,4-diol hydrochloride
$437.00
CAS No.: 276862-76-1
Catalog No.: 195710
Purity: 95%
MF: C4H10ClNO2
MW: 139.582
Storage: 2-8 degree Celsius
SMILES: Cl.N1C[C@@H]([C@H](C1)O)O
Catalog No.: 195710
Purity: 95%
MF: C4H10ClNO2
MW: 139.582
Storage: 2-8 degree Celsius
SMILES: Cl.N1C[C@@H]([C@H](C1)O)O
(3S,4S)-pyrrolidine-3,4-diol hydrochloride; CAS No.: 276862-76-1; (3S,4S)-pyrrolidine-3,4-diol hydrochloride. PROPERTIES: (3S,4S)-pyrrolidine-3,4-diol hydrochloride has molecular formula C5H12ClN {HCl, giving it a molecular weight of 153.07 g/mol. It appears as a white crystalline powder with a melting point between 195-198 C. The compound demonstrates good chemical stability under standard conditions but is hygroscopic. Recommended storage involves keeping it in a tightly sealed container at room temperature (15-25 C) with desiccants. Safety data indicates it may cause respiratory irritation and requires use of chemical splash goggles and lab coats during handling. The compound has a logP value of approximately 0.5 and exhibits high aqueous solubility. APPLICATIONS: This (3S,4S)-pyrrolidine-3,4-diol hydrochloride is extensively used in the synthesis of antiviral medications. Its pyrrolidine-diol structure provides a platform for developing nucleoside analogs targeting viral DNA polymerases. A clinical trial reported in Antiviral Research highlighted its role in developing agents for hepatitis B virus with improved resistance profiles. In pharmaceutical applications, it serves as a building block for synthesizing kinase inhibitors. The diol groups provide hydrogen-bonding interactions beneficial for optimizing kinase hinge binding. Research in the Journal of Medicinal Chemistry demonstrated its utility in developing pan-RAF kinase inhibitors for cancer therapy. Additionally, the compound is utilized in the preparation of pyrrolidine-containing fluorescent probes. The diol groups provide sites for installing fluorescence tags, enabling detection of enzymatic activity in biological systems, as reported in Bioconjugate Chemistry.
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