3-(4-(trifluoromethoxy)phenoxy)pyrrolidine
$400.00
CAS No.: 946715-68-0
Catalog No.: 195276
Purity: 95%
MF: C11H12F3NO2
MW: 247.216
Storage: 2-8 degree Celsius
SMILES: FC(OC1=CC=C(OC2CNCC2)C=C1)(F)F
Catalog No.: 195276
Purity: 95%
MF: C11H12F3NO2
MW: 247.216
Storage: 2-8 degree Celsius
SMILES: FC(OC1=CC=C(OC2CNCC2)C=C1)(F)F
3-(4-(trifluoromethoxy)phenoxy)pyrrolidine; CAS No.: 946715-68-0; 3-(4-(trifluoromethoxy)phenoxy)pyrrolidine. PROPERTIES: 3-(4-(trifluoromethoxy)phenoxy)pyrrolidine appears as a colorless to pale yellow liquid with a slight amine odor. Its molecular formula is C11H13F3NO2, corresponding to a molecular weight of approximately 256.22 g/mol. The compound exhibits a boiling point around 150-155 C at 760 mmHg and a density of about 1.2 g/cm? at 25 C. It demonstrates moderate solubility in common organic solvents such as methanol, acetone, and diethyl ether but is sparingly soluble in water. The substance is sensitive to oxidation and may form explosive peroxides upon prolonged storage. Proper storage requires keeping it in a tightly sealed, amber glass container with a suitable stabilizer, in a cool, dry location away from direct sunlight and heat sources. The temperature should be maintained below 10 C if possible. Safety precautions include using chemical-resistant gloves, safety goggles, and lab coats to prevent skin absorption and inhalation of vapors. The compound may cause skin and eye irritation, and accidental ingestion may be harmful. In case of exposure, immediate rinsing with water and medical consultation is recommended. APPLICATIONS: 3-(4-(trifluoromethoxy)phenoxy)pyrrolidine serves as a specialized intermediate in the synthesis of pharmaceuticals, particularly in the preparation of certain antidepressants and antipsychotics. Its pyrrolidine and trifluoromethoxy groups provide structural features important for receptor binding and bioactivity. In materials science, it functions as a building block for creating liquid crystal polymers and electro-optical materials, where its rigid aromatic structure and flexible pyrrolidine group enable desired mesomorphic properties and optical anisotropy. Additionally, it finds application in the development of fluorescent probes for bioimaging, where its phenoxy and trifluoromethoxy groups allow for selective labeling of biological targets such as proteins and lipids. The compound is also employed in the synthesis of agrochemicals, though specific applications in this area are limited to non-agricultural research settings.
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