2-(difluoromethyl)pyrrolidine hydrochloride
$300.00
CAS No.: 1781041-85-7
Catalog No.: 193001
Purity: 95%
MF: C5H10ClF2N
MW: 157.591
Storage: 2-8 degree Celsius
SMILES: Cl.FC(C1NCCC1)F
Catalog No.: 193001
Purity: 95%
MF: C5H10ClF2N
MW: 157.591
Storage: 2-8 degree Celsius
SMILES: Cl.FC(C1NCCC1)F
2-(difluoromethyl)pyrrolidine hydrochloride; CAS No.: 1781041-85-7; 2-(difluoromethyl)pyrrolidine hydrochloride. PROPERTIES: This compound appears as a white to off-white crystalline solid with molecular formula C5H10F2N2 {HCl and a molecular weight of 154.60 g/mol. It exhibits a melting point in the range of 188-192 C and demonstrates good solubility in water and common polar solvents like methanol. The substance is hygroscopic and should be stored in dry conditions. Recommended storage involves maintaining in tightly sealed containers at room temperature with protection from moisture and light. When handling, standard laboratory safety protocols should be observed, including the use of gloves and eye protection, as 2-(difluoromethyl)pyrrolidine hydrochloride may cause skin and eye irritation. The difluoromethyl group requires careful handling in strongly basic environments. APPLICATIONS: In medicinal chemistry, 2-(difluoromethyl)pyrrolidine hydrochloride serves as a key intermediate for synthesizing antiviral agents, as documented in pharmaceutical research focusing on nucleoside analogs. Its difluoromethyl substituent enables improved metabolic stability in biological systems. Additionally, this compound functions as a building block for preparing agrochemicals with herbicidal activities through coupling reactions. Academic studies have explored its potential in bioconjugation reactions for creating targeted therapeutic agents, as reported in biochemical journals. The pyrrolidine ring system also facilitates coordination with metal ions, making it valuable for creating coordination polymers in materials science applications, as evidenced by structural chemistry publications.
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