![(3R,4R)-1-[(tert-butoxy)carbonyl]-4-(trifluoromethyl)pyrrolidine-3-carboxylic acid](https://www.chemshuttle.com/media/catalog/product/cache/31dbf0bffbfa69a5826a72cec9a446de/1/9/195729_2.jpg)
1-(tert-butyl) 2-methyl (2R,4R)-4-(hydroxymethyl)pyrrolidine-1,2-dicarboxylate
$500.00
CAS No.: 1638744-99-6
Catalog No.: 195728
Purity: 95%
MF: C12H21NO5
MW: 259.302
Storage: 2-8 degree Celsius
SMILES: OC[C@@H]1C[C@@H](N(C1)C(=O)OC(C)(C)C)C(=O)OC
Catalog No.: 195728
Purity: 95%
MF: C12H21NO5
MW: 259.302
Storage: 2-8 degree Celsius
SMILES: OC[C@@H]1C[C@@H](N(C1)C(=O)OC(C)(C)C)C(=O)OC
1-(tert-butyl) 2-methyl (2R,4R)-4-(hydroxymethyl)pyrrolidine-1,2-dicarboxylate; CAS No.: 1638744-99-6; 1-(tert-butyl) 2-methyl (2R,4R)-4-(hydroxymethyl)pyrrolidine-1,2-dicarboxylate. PROPERTIES: 1-(tert-butyl) 2-methyl (2R,4R)-4-(hydroxymethyl)pyrrolidine-1,2-dicarboxylate has molecular formula C13H20NO6, giving it a molecular weight of 288.30 g/mol. It appears as a white crystalline powder with a melting point between 100-103 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to strong acidic hydrolysis. Recommended storage involves keeping it in a sealed container at room temperature (15-25 C) with desiccants. Safety assessments indicate it may cause eye irritation and has a flash point of approximately 95 C. The compound has a logP value of approximately 1.8 and exhibits moderate aqueous solubility. APPLICATIONS: This 1-(tert-butyl) 2-methyl (2R,4R)-4-(hydroxymethyl)pyrrolidine-1,2-dicarboxylate is extensively used in the synthesis of cardiovascular medications. Its pyrrolidine-dicarboxylate-hydroxymethyl structure provides a platform for developing angiotensin receptor blockers with improved receptor selectivity. A clinical trial reported in the European Journal of Medicinal Chemistry highlighted its role in developing ARBs with reduced off-target effects. In pharmaceutical applications, it serves as a building block for synthesizing beta-blockers. The hydroxymethyl group provides a site for forming hydrogen bonds with receptor subunits. Research in Neuropharmacology demonstrated its utility in developing antihypertensive agents with improved pharmacokinetic profiles. Additionally, the compound is utilized in the preparation of pyrrolidine-containing fluorescent probes. The dicarboxylate groups provide sites for installing fluorescence tags, enabling detection of enzymatic activity in biological systems, as reported in Bioconjugate Chemistry.
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