![8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one](https://www.chemshuttle.com/media/catalog/product/cache/31dbf0bffbfa69a5826a72cec9a446de/1/7/177229_2.jpg)
6-(methylthio)pyrimido[5,4-d]pyrimidin-4(1H)-one
$300.00
CAS No.: 98550-19-7
Catalog No.: 196192
Purity: 95%
MF: C7H6N4OS
MW: 194.219
Storage: 2-8 degree Celsius
SMILES: CSC=1N=CC=2NC=NC(C2N1)=O
Catalog No.: 196192
Purity: 95%
MF: C7H6N4OS
MW: 194.219
Storage: 2-8 degree Celsius
SMILES: CSC=1N=CC=2NC=NC(C2N1)=O
6-(methylthio)pyrimido[5,4-d]pyrimidin-4(1H)-one; CAS No.: 98550-19-7; 6-(methylthio)pyrimido[5,4-d]pyrimidin-4(1H)-one. PROPERTIES: This compound presents a 6-(methylthio)pyrimido[5,4-d]pyrimidin-4(1H)-one structure, combining a methylthio group and a pyrimido[5,4-d]pyrimidin-4(1H)-one framework. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 238.2 g/mol (C8H7N5OS). The melting point ranges between 220-225 C, and it exhibits moderate solubility in common organic solvents like DMSO and DMF while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 6-(Methylthio)pyrimido[5,4-d]pyrimidin-4(1H)-one serves as a specialized intermediate in pharmaceutical and chemical synthesis. Its 6-(methylthio)pyrimido[5,4-d]pyrimidin-4(1H)-one structure enables participation in various reactions, including oxidation of the methylthio group to sulfone and nucleophilic substitution at the pyrimidine ring. In medicinal chemistry, it is used to develop enzyme inhibitors and receptor modulators, particularly those targeting kinases and nucleic acid-binding proteins. The methylthio group can be oxidized to sulfone to enhance water solubility or undergo displacement reactions to introduce various substituents. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies employ it as a model compound in Medicinal Chemistry journals, focusing on the development of novel pyrimidopyrimidine derivatives based on the 6-(methylthio)pyrimido[5,4-d]pyrimidin-4(1H)-one scaffold.
Reviews
Write Your Own Review