4-chloro-2,6-dimethylpyrimidine
$300.00
CAS No.: 4472-45-1
Catalog No.: 196426
Purity: 95%
MF: C6H7ClN2
MW: 142.589
Storage: 2-8 degree Celsius
SMILES: ClC1=NC(=NC(=C1)C)C
Catalog No.: 196426
Purity: 95%
MF: C6H7ClN2
MW: 142.589
Storage: 2-8 degree Celsius
SMILES: ClC1=NC(=NC(=C1)C)C
4-chloro-2,6-dimethylpyrimidine; CAS No.: 4472-45-1; 4-chloro-2,6-dimethylpyrimidine. PROPERTIES: This compound features a 4-chloro-2,6-dimethylpyrimidine structure, combining a chloro substituent and two methyl groups on the pyrimidine framework. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 149.0 g/mol (C6H6ClN2). The melting point ranges between 100-105 C, and it exhibits moderate solubility in common organic solvents like ethyl acetate, dichloromethane, and tetrahydrofuran while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 4-Chloro-2,6-dimethylpyrimidine serves as a versatile intermediate in pharmaceutical and chemical synthesis. Its 4-chloro-2,6-dimethylpyrimidine structure allows for participation in various reactions, including nucleophilic substitution at the chloro position and electrophilic substitution at the pyrimidine ring. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The chloro substituent provides a handle for introducing aryl, vinyl, or heterocyclic substituents. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies employ it as a model compound in Medicinal Chemistry journals, focusing on optimizing the 4-chloro-2,6-dimethylpyrimidine scaffold for improved biological activity and pharmacokinetic properties.
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