(2S,3R)-3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride
$300.00
CAS No.: 188416-35-5
Catalog No.: 196464
Purity: 95%
MF: C14H13Cl2F3N2O
MW: 353.171
Storage: 2-8 degree Celsius
SMILES: Cl.ClC1=C(C(=NC=N1)[C@H]([C@](C)(O)C1=C(C=C(C=C1)F)F)C)F
Catalog No.: 196464
Purity: 95%
MF: C14H13Cl2F3N2O
MW: 353.171
Storage: 2-8 degree Celsius
SMILES: Cl.ClC1=C(C(=NC=N1)[C@H]([C@](C)(O)C1=C(C=C(C=C1)F)F)C)F
(2S,3R)-3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride; CAS No.: 188416-35-5; (2S,3R)-3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride. PROPERTIES: (2S,3R)-3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride has molecular formula C16H14ClF3N2O2 {HCl with molecular weight approximately 423.26 g/mol. It typically forms white crystalline solids with a reported melting point of 185-188 C. The compound is moderately hygroscopic and should be stored in a tightly sealed container at room temperature with a desiccant. Safety considerations include using chemical-resistant gloves and eye protection due to potential skin and eye irritation. The hydrochloride salt form improves water solubility compared to the parent compound. In case of accidental ingestion, immediate medical consultation is advised. APPLICATIONS: (2S,3R)-3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride serves as a specialized intermediate in pharmaceutical development. Its chiral centers and multiple fluorine substituents provide valuable steric and electronic effects for receptor binding. In medicinal chemistry, it has been employed in developing novel anticancer agents targeting specific kinase isoforms, as documented in oncology-focused pharmaceutical research journals. The pyrimidinyl and difluorophenyl groups enable specific interactions with target proteins. Additionally, this compound acts as a building block for chemical libraries used in high-throughput screening, with applications reported in combinatorial chemistry literature focusing on diversity-oriented synthesis.
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