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(2-methylpyrimidin-5-yl)methanol; CAS No.: 2239-83-0; This pyrimidine methanol exemplifies our pharma building blocks for kinase hinge-binding motif design. The 2-methylpyrimidine and hydroxymethyl group enable hydrogen bonding optimization. Our Vilsmeier-Haack formylation achieves regioselective oxidation. The product supports development of third-generation EGFR inhibitors targeting T790M mutations.