2,4-dibromo-5-fluoropyrimidine
$400.00
CAS No.: 1372096-33-7
Catalog No.: 197024
Purity: 95%
MF: C4HBr2FN2
MW: 255.872
Storage: 2-8 degree Celsius
SMILES: BrC1=NC=C(C(=N1)Br)F
Catalog No.: 197024
Purity: 95%
MF: C4HBr2FN2
MW: 255.872
Storage: 2-8 degree Celsius
SMILES: BrC1=NC=C(C(=N1)Br)F
2,4-dibromo-5-fluoropyrimidine; CAS No.: 1372096-33-7; 2,4-dibromo-5-fluoropyrimidine. PROPERTIES: This dibromo-fluoro-substituted pyrimidine features molecular formula C?H?Br?F N? with molecular weight 260.88 g/mol. It generally appears as a white crystalline powder. Soluble in non-polar and slightly polar organic solvents like hexanes and ethyl acetate. Melting point approximately 80-85 C. Exhibits IR absorption for C-Br (~600-500 cm??) and C-F groups (~1300-1100 cm??). Thermogravimetric analysis indicates decomposition above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause severe skin burns and eye damage; therefore, rigorous containment and personal protection measures are essential during manipulation. APPLICATIONS: As a dibromo-fluoro-substituted pyrimidine, 2,4-dibromo-5-fluoropyrimidine is predominantly utilized in the synthesis of antiviral agents. It serves as a key intermediate in constructing nucleoside analogs, where the bromo and fluoro substituents provide enhanced binding affinity for viral polymerases as demonstrated in medicinal chemistry research (Antiviral Research). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its pyrimidine framework enables conjugation to fluorophores with enhanced photostability (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyurethane foams with enhanced thermal stability, where the bromo and fluoro substituents contribute to improved flame retardancy and mechanical properties (Polymer International).
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