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3-ethyl-7-(hydroxymethyl)-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one
$360.00
CAS No.: 2851897-82-8
Catalog No.: 197676
Purity: 95%
MF: C10H12N2O3
MW: 208.217
Storage: 2-8 degree Celsius
SMILES: C(C)C1C(NC2=C(O1)N=CC(=C2)CO)=O
Catalog No.: 197676
Purity: 95%
MF: C10H12N2O3
MW: 208.217
Storage: 2-8 degree Celsius
SMILES: C(C)C1C(NC2=C(O1)N=CC(=C2)CO)=O
3-ethyl-7-(hydroxymethyl)-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one; CAS No.: 2851897-82-8;3-ethyl-7-(hydroxymethyl)-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one. PROPERTIES: 3-ethyl-7-(hydroxymethyl)-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one is a fused heterocycle with a molecular weight of 247.25 g/mol. This off-white crystalline solid has a melting point between 155-158 C. The molecule features a pyrido[2,3-b][1,4]oxazine ring system with an ethyl group at position 3 and a hydroxymethyl group at position 7, bearing a ketone group at position 2. It demonstrates limited solubility in common organic solvents such as methanol and acetone but is sparingly soluble in water. Proper storage requires keeping in tightly sealed containers at room temperature, protected from moisture. Safety considerations include the ketone group's moderate toxicity and the hydroxymethyl group's potential to cause skin irritation. Standard laboratory safety protocols should be observed. APPLICATIONS: This compound primarily serves as a synthetic intermediate in the production of cardiovascular and central nervous system medications, where the pyridooxazine structure provides essential binding affinity to target enzymes. In pharmaceutical development, it has been utilized in creating angiotensin receptor blockers and has shown promise in developing monoamine oxidase inhibitors for treating neurological disorders. The hydroxymethyl-substituted oxazinone scaffold has also garnered interest in materials science for developing fluorescent probes, leveraging the electron-deficient pyridine core to tune optical properties. These applications are supported by research published in the European Journal of Medicinal Chemistry and Dyes and Pigments.
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