3-chloro-6-phenylpyridazine
$400.00
CAS No.: 20375-65-9
Catalog No.: 196383
Purity: 95%
MF: C10H7ClN2
MW: 190.633
Storage: 2-8 degree Celsius
SMILES: ClC=1N=NC(=CC1)C1=CC=CC=C1
Catalog No.: 196383
Purity: 95%
MF: C10H7ClN2
MW: 190.633
Storage: 2-8 degree Celsius
SMILES: ClC=1N=NC(=CC1)C1=CC=CC=C1
3-chloro-6-phenylpyridazine; CAS No.: 20375-65-9; 3-chloro-6-phenylpyridazine. PROPERTIES: This compound presents a 3-chloro-6-phenylpyridazine structure, combining a chloro substituent and a phenyl group on the pyridazine framework. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 186.6 g/mol (C9H6ClN2). The melting point ranges between 100-105 C, and it exhibits moderate solubility in common organic solvents like ethyl acetate, dichloromethane, and tetrahydrofuran while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 3-Chloro-6-phenylpyridazine serves as a specialized intermediate in pharmaceutical research. Its 3-chloro-6-phenylpyridazine structure enables diverse reactivity patterns, including nucleophilic substitution at the chloro position and electrophilic substitution at the pyridazine ring. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The phenyl group provides additional conjugation that enhances binding to biological targets. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies utilize it as a model system in Medicinal Chemistry journals, focusing on optimizing the 3-chloro-6-phenylpyridazine scaffold for improved biological activity and pharmacokinetic properties.
Reviews
Write Your Own Review