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5-bromopyrazolo[1,5-a]pyrimidine
$400.00
CAS No.: 1159981-95-9
Catalog No.: 196359
Purity: 95%
MF: C6H4BrN3
MW: 198.023
Storage: 2-8 degree Celsius
SMILES: BrC1=NC=2N(C=C1)N=CC2
Catalog No.: 196359
Purity: 95%
MF: C6H4BrN3
MW: 198.023
Storage: 2-8 degree Celsius
SMILES: BrC1=NC=2N(C=C1)N=CC2
5-bromopyrazolo[1,5-a]pyrimidine; CAS No.: 1159981-95-9; 5-bromopyrazolo[1,5-a]pyrimidine. PROPERTIES: This compound presents a 5-bromopyrazolo[1,5-a]pyrimidine structure, combining a bromine atom and a pyrazolopyrimidine framework. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 226.0 g/mol (C7H4BrN3). The melting point ranges between 140-145 C, and it exhibits moderate solubility in common organic solvents like DMSO and DMF while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 5-Bromopyrazolo[1,5-a]pyrimidine serves as a specialized intermediate in pharmaceutical research. Its 5-bromopyrazolo[1,5-a]pyrimidine structure enables diverse reactivity patterns, including palladium-catalyzed cross-coupling reactions at the bromine position and nucleophilic substitution at the pyrimidine ring. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The bromine atom provides a handle for introducing aryl, vinyl, or heterocyclic substituents. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies utilize it as a model system in Medicinal Chemistry journals, focusing on optimizing the 5-bromopyrazolo[1,5-a]pyrimidine scaffold for improved biological activity and target engagement.
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