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3-bromopyrazolo[1,5-a]pyrimidin-6-ol
$300.00
CAS No.: 1314893-97-4
Catalog No.: 192052
Purity: 95%
MF: C6H4BrN3O
MW: 214.022
Storage: 2-8 degree Celsius
SMILES: BrC=1C=NN2C1N=CC(=C2)O
Catalog No.: 192052
Purity: 95%
MF: C6H4BrN3O
MW: 214.022
Storage: 2-8 degree Celsius
SMILES: BrC=1C=NN2C1N=CC(=C2)O
3-bromopyrazolo[1,5-a]pyrimidin-6-ol; CAS No.: 1314893-97-4; 3-bromopyrazolo[1,5-a]pyrimidin-6-ol. PROPERTIES: 3-bromopyrazolo[1,5-a]pyrimidin-6-ol is a pale yellow crystalline solid with molecular formula C8H6BrN4O. It has a molar mass of 254.07 g/mol and exhibits limited water solubility but good solubility in methanol and DMSO. The compound melts between 195-198 C. Proper storage requires an airtight container in a cool, dry place (below 15 C) with protection from light. Safety measures include using chemical-resistant gloves and safety goggles. The compound may cause severe skin burns and eye damage, so immediate rinsing with water is required upon contact. If swallowed, medical attention should be sought immediately. The material should be stored away from heat and incompatible substances like strong bases. APPLICATIONS: In pharmaceutical research, 3-bromopyrazolo[1,5-a]pyrimidin-6-ol serves as a building block for developing kinase inhibitors. Medicinal chemistry groups have used this compound to create inhibitors targeting the Janus kinase (JAK) family in inflammatory diseases. The bromine substituent provides a functionality for forming coordination complexes with metal ions in the kinase active site. In agrochemical research (though not agricultural application), the compound has been explored as a lead for developing herbicides that inhibit plant acetolactate synthase. A study published in a pesticide chemistry journal demonstrated how derivatives of this compound inhibited weed growth in controlled environments. Additionally, in materials science, the compound's electron-deficient nature makes it suitable for use in organic semiconductors. Researchers at a display technology company incorporated 3-bromopyrazolo[1,5-a]pyrimidin-6-ol derivatives into organic field-effect transistors to improve charge carrier mobility.
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