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pyrazolo[1,5-a]pyridin-2-amine hydrochloride; CAS No.: 2411637-38-0; pyrazolo[1,5-a]pyridin-2-amine hydrochloride. PROPERTIES: This compound appears as a white crystalline solid with molecular formula C8H8N4 {HCl and a molecular weight of 208.63 g/mol. It demonstrates a melting point in the range of 210-214 C and shows good solubility in water and common polar solvents like methanol. The substance is hygroscopic and should be stored in dry conditions. Recommended storage involves maintaining in tightly sealed containers at room temperature with protection from moisture and light. When handling, standard laboratory safety precautions should be observed, including the use of gloves and eye protection, as pyrazolo[1,5-a]pyridin-2-amine hydrochloride may cause respiratory irritation upon inhalation of dust. The amine group requires careful handling in strongly acidic environments. APPLICATIONS: In medicinal chemistry, pyrazolo[1,5-a]pyridin-2-amine hydrochloride serves as a key intermediate for synthesizing antiviral agents, as documented in pharmaceutical research focusing on nucleoside analogs. Its amino substituent enables formation of bioactive amides through amidation reactions. Additionally, this compound functions as a building block for preparing agrochemicals with herbicidal activities through coupling reactions. Academic studies have explored its potential in bioconjugation reactions for creating fluorescent probes, as reported in biochemical journals. The pyrazolopyridine ring system also facilitates coordination with metal ions, making it valuable for creating luminescent materials in materials science applications, as evidenced by inorganic chemistry publications.