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ethyl 4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate; CAS No.: 30720-25-3; Ethyl 4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate combines chloro and ester functionalities for sequential derivatization. The N-ethyl group enhances metabolic stability compared to unprotected pyrazoles. ChemShuttle functions as a worldwide chemical supplier of substituted pyrazolopyridines. Our synthesis employs tandem cyclization-chlorination sequences for efficient production. The compound serves as a key intermediate for JAK/STAT pathway inhibitors through palladium-catalyzed cross-coupling.