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5-fluoro-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile
$300.00
CAS No.: 1256833-42-7
Catalog No.: 196958
Purity: 95%
MF: C7H3FN4
MW: 162.127
Storage: 2-8 degree Celsius
SMILES: FC=1C=C2C(=NC1)NN=C2C#N
Catalog No.: 196958
Purity: 95%
MF: C7H3FN4
MW: 162.127
Storage: 2-8 degree Celsius
SMILES: FC=1C=C2C(=NC1)NN=C2C#N
5-fluoro-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile; CAS No.: 1256833-42-7; 5-fluoro-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile. PROPERTIES: This fluoro-substituted pyrazolopyridine nitrile features molecular formula C?H?FN? with molecular weight 159.13 g/mol. It typically exists as a white crystalline powder. Soluble in polar aprotic solvents like DMF and DMSO. Melting point approximately 130-135 C. Exhibits IR absorption for cyano (~2220 cm??) and C-F groups (~1300-1100 cm??). Thermogravimetric analysis indicates decomposition above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause mild skin irritation and serious eye damage; therefore, standard laboratory safety precautions including protective clothing and eye protection are recommended during handling. APPLICATIONS: As a fluoro-substituted pyrazolopyridine nitrile, 5-fluoro-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile is predominantly utilized in the synthesis of kinase inhibitors. It serves as a key intermediate in constructing the core scaffold of these compounds, where the pyrazolopyridine ring provides enhanced binding affinity for the kinase active site as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its nitrile functionality enables conjugation to biomolecules via click chemistry reactions (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyurethane foams with enhanced thermal stability, where the fluoro substituent contributes to improved flame retardancy and mechanical properties (Polymer International).
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