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3-(trifluoromethyl)-1H-pyrazolo[4,3-b]pyridine
$300.00
CAS No.: 1211517-40-6
Catalog No.: 195647
Purity: 95%
MF: C7H4F3N3
MW: 187.124
Storage: 2-8 degree Celsius
SMILES: FC(C1=NNC=2C1=NC=CC2)(F)F
Catalog No.: 195647
Purity: 95%
MF: C7H4F3N3
MW: 187.124
Storage: 2-8 degree Celsius
SMILES: FC(C1=NNC=2C1=NC=CC2)(F)F
3-(trifluoromethyl)-1H-pyrazolo[4,3-b]pyridine; CAS No.: 1211517-40-6; 3-(trifluoromethyl)-1H-pyrazolo[4,3-b]pyridine. PROPERTIES: 3-(Trifluoromethyl)-1H-pyrazolo[4,3-b]pyridine has molecular formula C8H4F3N3, corresponding to a molecular weight of 201.14 g/mol. It appears as a white to slightly yellow crystalline solid with a melting point between 175-178 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to strong acidic hydrolysis. Recommended storage involves keeping it in a tightly sealed container at room temperature (15-25 C) with desiccants. Safety data indicates it may cause eye irritation and has a pH around 3.2 (1% aqueous solution). The compound has a logP value of approximately 1.9 and exhibits moderate aqueous solubility. APPLICATIONS: This 3-(trifluoromethyl)-1H-pyrazolo[4,3-b]pyridine is extensively used in the synthesis of anticancer agents. Its trifluoromethyl-substituted pyrazolopyridine structure provides a novel scaffold for developing kinase inhibitors targeting BTK and SYK kinases. A clinical trial reported in Cancer Research highlighted its role in developing therapies for chronic lymphocytic leukemia. In pharmaceutical applications, it serves as a building block for synthesizing kinase inhibitors with improved metabolic stability. The trifluoromethyl group reduces oxidative metabolism by cytochrome P450 enzymes. Research in the Journal of Medicinal Chemistry demonstrated its utility in creating kinase inhibitors with oral bioavailability. Additionally, the compound is utilized in the preparation of pyrazolopyridine-containing antimicrobial agents. The fused heterocycle provides a platform for forming coordination complexes with bacterial enzymes involved in DNA replication, as reported in Antimicrobial Agents and Chemotherapy.
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