2-(p-tolyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine; CAS No.: 1250443-99-2;2-(p-tolyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine. PROPERTIES: 2-(p-tolyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine is a substituted heterocycle with a molecular weight of 267.36 g/mol. This off-white crystalline solid has a melting point between 108-111 C. The molecule features a pyrazolo[1,5-a]pyrazine ring system with tetrahydro substitution and a p-tolyl group at position 2. It demonstrates moderate solubility in common organic solvents such as toluene and chloroform but limited water solubility. Proper storage involves keeping in tightly sealed containers at room temperature, protected from light and moisture. Safety considerations include the methyl-substituted aromatic group's potential to cause skin irritation and the heterocycle's general toxicity. Proper protective equipment should be utilized during handling. APPLICATIONS: This compound primarily serves as a building block in the synthesis of cardiovascular and central nervous system medications, where the tolyl-substituted pyrazolopyrazine structure provides essential binding affinity to target enzymes. In pharmaceutical development, it has been utilized in the synthesis of beta-blockers and has shown promise in creating serotonin receptor modulators for treating psychiatric disorders. The tetrahydropyrazolopyrazine scaffold has also garnered interest in materials science for developing fluorescent probes, leveraging the electron-donating tolyl group to tune optical properties. These applications are supported by research published in the Journal of Medicinal Chemistry and Dyes and Pigments.