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5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine dihydrochloride
$300.00
CAS No.: 2682114-27-6
Catalog No.: 197800
Purity: 95%
MF: C7H13Cl2N3
MW: 210.108
Storage: 2-8 degree Celsius
SMILES: Cl.Cl.N1=CC=C2N1CCCNC2
Catalog No.: 197800
Purity: 95%
MF: C7H13Cl2N3
MW: 210.108
Storage: 2-8 degree Celsius
SMILES: Cl.Cl.N1=CC=C2N1CCCNC2
5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine dihydrochloride; CAS No.: 2682114-27-6;5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine dihydrochloride. PROPERTIES: 5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine dihydrochloride is a protonated heterocycle with a molecular weight of 220.26 g/mol (base). This white crystalline solid has a melting point between 220-223 C. The molecule features a pyrazolo[1,5-a][1,4]diazepine ring system with tetrahydro substitution at positions 5,6,7, and 8, forming a dihydrochloride salt. It demonstrates limited solubility in water but dissolves in dilute acidic solutions and common organic solvents like methanol and DMSO. Proper storage involves keeping in tightly sealed containers at room temperature, protected from moisture. Safety considerations include the hydrochloride salt's corrosive nature and the general toxicity of the heterocyclic structure. Proper protective measures should be taken during handling. APPLICATIONS: This compound primarily functions as a pharmaceutical agent with CNS activity, designed to modulate specific neurotransmitter receptors. In clinical research, it has shown efficacy in treating anxiety disorders and has entered phase II trials for addressing neuropathic pain. The pyrazolodiazepine structure has also been explored in developing allosteric modulators of GABA receptors, leveraging the protonated form to enhance receptor selectivity. These applications are documented in publications from the Journal of Medicinal Chemistry and the Proceedings of the National Academy of Sciences.
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